A proposal on a new EU regulatory framework for Registration, Evaluation and Authorisation of Chemicals (REACH) was adopted 29 October 2003 by the European Commission. REACH aims to improve the protection of human health and the environment while maintaining the competitiveness and enhancing the innovative capability of the EU chemicals industry.

In CAESAR we addressed with (Q)SAR models five of the endpoints defined within the list of priority regulatory endpoints(*) given in the following table:

1
Two-generation reprotoxicity
2
Developmental toxicity studies
3
Further mutagenicity studies
4
Skin sensitisation
5
Long-term fish toxicity
6
Developmental toxicity screening
7
Accumulation
8
Short-term repeated dose
9
Carcinogenicity
10
Sub-chronic toxicity
11
Long-term repeated toxicity
12
Short-term fish toxicity
13
Acute inhalation toxicity
14
Acute dermal toxicity
15
Acute oral toxicity
16
In vivo eye irritation
17
In vivo skin irritation
18
Long-term bird toxicity


For more info on REACH, please visit:

Legislation (full text PDF)
http://eur-lex.europa.eu/LexUriServ/site/en/oj/2006/l_396/l_39620061230en00010849.pdf

DG Enterprise
http://europa.eu.int/comm/enterprise/reach

DG Environment
http://europa.eu.int/comm/environment/chemicals/reach.htm

(*) As defined in: Van der Jagt et al. (2004) Alternative approaches can reduce the use of test animals under REACH. Addendum to the report �Assessment of additional testing needs under REACH. Effects of (Q)SARS, risk based testing and voluntary industry initiatives�.