US EPA
United States Environmental Protection Agency
The US EPA website provides a number of freely available QSAR models. Both QSAR tools and specific models for selected endpoints can be used.
Official website: http://www.epa.gov/
AltTox.org
Non-animal Methods for Toxicity Testing
AltTox.org is a website dedicated to advancing non-animal methods of toxicity testing, both to better protect the health of humans, animals, and the environment and to reduce the numbers and suffering of animals used in current toxicology assessments. The website is designed to encourage the exchange of technical and policy information on in vitro and in silico methods for all types of toxicity tests. The target audience includes stakeholders in industry, government, academia, and nongovernmental organizations.
Official website: http://www.alttox.org/
DEMETRA
Development of Environmental Modules for Evaluation of Toxicity of pesticide Residues in Agriculture
Contract number: QLK5-CT-2002-00691
The objective of DEMETRA was to produce new public software for the toxicity prediction of pesticide. The software is available on the web, allowing prediction of pesticide toxicity in trout, daphnia, bee, quail (oral and dietary exposure) to facilitate the Dossier preparation for pesticide registration. Each of the predictive models incorporates an intelligent integration of several individual models for a given endpoint.
Official project website: http://www.demetra-tox.net/
RAINBOW
Research on Animal and In-vitro studies and Numerical methods: Bridging Opportunities through a Workshop
Contract number: LSSB-CT-2005-018695
The main objective of RAINBOW was to gather in a workshop communities with experience in animal and non-animal data and predictions from computer-based modelling to discuss how to achieve a better risk assessment (RA) of chemical compounds, integrating their experiences. The workshop was held in Milan on December 11-13, 2006 and it has been aimed at regulators, academic and industrial scientists and stakeholders such as chemical industries, animal welfare experts and public organizations. The workshop discussion was useful to break down barriers between scientific and societal areas. The REACH initiative has been discussed in its implications on the integration of methodologies.
Official project website: http://www.rainbow-project.eu/
SCARLET
StruCture-Activity Relationships Leading ExperTs in mutagenicity and carcinogenicity
Contract number: SP5A-CT-2007-044166
The SCARLET project is aimed to organise a workshop on in silico methods for carcinogenicity and mutagenicity, which will be held in Milan on 2-4 April, 2008. QSARs (Quantitative Structure Activity Relationships) for genotoxicity and carcinogenicity are gaining increasing importance for the risk assessment of chemicals. This workshop will bring together leading experts in this area to discuss the current state-of-the art, various application scenarios (e.g. in regulatory, industrial, scientific settings), current limitations, unsolved problems, research issues and new research directions.
Official project website: http://www.scarlet-project.eu/
OSIRIS
Optimized Strategies for Risk Assessment of Industrial Chemicals through Integration of Non-Test and Test Information
Contract number: 037017 (GOCE)
The goal of the project OSIRIS is to develop integrated testing strategies (ITS) fit for REACH, to significantly increase the use of non-testing information for regulatory decision making, and thus to minimize the need for animal testing. Operational procedures are developed, tested and disseminated for this purpose and to guide a transparent and scientifically sound evaluation of chemical substances in a risk-driven, context-specific and substance-tailored manner.
Official project website: http://www.osiris-reach.eu/
